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  • Title: Endoscopic identification of Peyer's patches of the terminal ileum in a patient with Crohn's disease.
    Author: Ishimoto H, Isomoto H, Shikuwa S, Wen CY, Suematu T, Ito M, Murata I, Ishibashi H, Kohno S.
    Journal: World J Gastroenterol; 2004 Sep 15; 10(18):2767-8. PubMed ID: 15309739.
    Abstract:
    We presented a 20-year-old patient with Crohn's disease (CD). Colonoscopy revealed longitudinal ulceration in the terminal ileum and rectal aphtoid ulcers. After treatment with mesalamine and total parenteral nutrition, repeat colonoscopy revealed a granular elevated area in the terminal ileum, which appeared as an irregular dome-like elevation with irregularly arranged villi on magnifying endoscopy. Biopsy specimens taken from the region showed microgranulomas and lymphoid hyperplasia. Scanning electron microscopy revealed the presence of M cells, confirming that the area corresponded to Peyer's patches. Peyer's patches by magnifying endoscopy and electron microscopy may provide insights into the pathogenesis of CD.
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