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  • Title: Canine ureteral replacement with long acellular matrix tube: is it clinically applicable?
    Author: Osman Y, Shokeir A, Gabr M, El-Tabey N, Mohsen T, El-Baz M.
    Journal: J Urol; 2004 Sep; 172(3):1151-4. PubMed ID: 15311060.
    Abstract:
    PURPOSE: We evaluated the effectiveness of acellular matrix used as a tube for replacement of a relatively long segment of the canine ureter. MATERIALS AND METHODS: Acellular matrix was obtained by excision of the whole ureter of donor dogs that were sacrificed and not included in the study group. Retrieved ureters were treated to have complete cell lysis, while maintaining the fiber framework. The study included 10 mongrel dogs in which a 3 cm segment was excised from 1 ureter and replaced by a tube of acellular matrix of the same length and width. The new tube was sutured proximal and distal by watertight interrupted sutures around a 5Fr Double-J stent (Medical Engineering Corp., New York, New York) that remained for 6 weeks. Excretory urography was done 1 and 2 weeks after stent removal and the dogs were then sacrificed. Before sacrifice the ureter was exposed and carefully examined, and the whole specimen was excised for histopathological examination. RESULTS: All dogs survived surgery except 1, which died 1 week postoperatively of a malpositioned stent and urinary ascites. There was no clinically apparent postoperative complications during the presence or after the removal of the ureteral stents. One week after stent removal excretory urography showed ipsilateral mild to moderate hydroureteronephrosis in 3 dogs and no dye excretion in 6 with a normal contralateral kidney. One week later no dye excretion was detected in all except 1 dog, which showed more radiological deterioration. At the time of sacrifice there was moderate to marked hydroureteronephrosis above the level of the new tube in all dogs. Although the graft was intact in all subjects, marked shrinkage was observed. On ureteral calibration there was significant narrowing of the lumen up to complete occlusion. At 8 weeks histopathological examination showed extensive fibrosis. CONCLUSIONS: An acellular matrix tube is not able to replace a 3 cm segment of the canine ureter.
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