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  • Title: Cholestasis of pregnancy, pruritus and 5-hydroxytryptamine 3 receptor antagonists.
    Author: Schumann R, Hudcova J.
    Journal: Acta Obstet Gynecol Scand; 2004 Sep; 83(9):861-2. PubMed ID: 15315599.
    Abstract:
    Pruritus, an early symptom of intrahepatic cholestasis of pregnancy, may be severe. Conventional treatment includes ursodeoxycholic acid and cholestyramine. Ondansetron, a 5-hydroxytryptamine 3 receptor antagonist antiemetic, has been shown to reduce pruritus of different etiologies including cholestasis. We now report the successful preoperative use of ondansetron in a patient with pruritus from intrahepatic cholestasis of pregnancy. While the mechanism for our patient's response is poorly understood, 5-hydroxytryptamine 3 receptor antagonists should be further evaluated and possibly considered as a treatment option for intrahepatic cholestasis of pregnancy-related pruritus.
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