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  • Title: The role of insulin-like growth factor-I in hyaluronan mediated repair of cultured cartilage explants.
    Author: Homandberg GA, Ummadi V, Kang H.
    Journal: Inflamm Res; 2004 Aug; 53(8):396-404. PubMed ID: 15316671.
    Abstract:
    OBJECTIVE AND DESIGN: To test whether hyaluronan (HA) restores proteoglycan (PG) in fibronectin fragment (Fn-f) damaged cartilage through activities of insulin-like growth factor 1 (IGF-1). MATERIAL: Bovine cartilage explants were studied. METHODS: Cartilage PG content was measured by a dye binding assay. PG synthesis was measured by incorporation of radiolabeled sulfate. Release of IGF-1 from explants was measured by ELISA. RESULTS: Higher mass HA forms were more reparative than smaller and enhanced PG synthesis in explants, but not in monolayer cultures. Higher mass HA enhanced PG synthesis and retention of IGF-1 within the explants while IGF-1 binding proteins decreased activities of HA. CONCLUSIONS: The reparative effects of HA appear to involve enhanced PG synthesis through IGF-1 and requires cartilage matrix.
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