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  • Title: Altered aspartate in Alzheimer neurofibrillary tangles.
    Author: Payan IL, Chou SJ, Fisher GH, Man EH, Emory C, Frey WH.
    Journal: Neurochem Res; 1992 Feb; 17(2):187-91. PubMed ID: 1531702.
    Abstract:
    Normal protein-bound L-aspartyl/L-asparaginyl residues may undergo post-translational modification by racemization to D-aspartate, or by isomerization to the L-isoaspartyl form in which the peptide chain links through the beta carboxyl group of the residue. Based on preliminary results reported here, proteins associated with Alzheimer neurofibrillary tangle preparations contain a significantly greater number of these modified aspartyl residues than the unaffected proteins from the surrounding gray matter or in comparable preparations from normal brains.
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