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  • Title: Interactions of 5-deazapteridine derivatives with Mycobacterium tuberculosis and with human dihydrofolate reductases.
    Author: da Cunha EF, de Castro Ramalho T, Bicca de Alencastro R, Maia ER.
    Journal: J Biomol Struct Dyn; 2004 Oct; 22(2):119-30. PubMed ID: 15317473.
    Abstract:
    There are major differences between the structures of human dihydrofolate reductase (hDHFR) and Mycobacterium tuberculosis dihydrofolate reductase (mtDHFR). These differences may allow us to design more selective mtDHFR inhibitors. In this paper we study the reactions of six different compounds derived from 5-deazapteridine with human and bacterial enzymes. Results suggest that the addition of hydrophobic groups to the aminophenyl ring would increase mtDHFR-inhibitor affinity and selectivity.
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