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  • Title: Clonal elimination of self reactive V beta 6+ T cells induced by H-2 products expressed on thymic radio-resistant components.
    Author: Arase H, Arase N, Ogasawara K, Good RA, Onoè K.
    Journal: Int Immunol; 1992 Jan; 4(1):75-82. PubMed ID: 1531766.
    Abstract:
    The role of thymic radio-resistant cells on clonal elimination of V beta 6+ T cells that are reactive to minor lymphocyte stimulatory (Mls)-1a plus I-E antigens has been investigated. Previous studies with allogeneic bone marrow chimeras revealed that radio-sensitive I-E+ cells derived from donor bone marrow in the thymus play a major role in the clonal elimination of V beta 6+ T cells. However, we could show that not only the thymic bone marrow derived components but also the radio-resistant ones (presumably thymic epithelial cells) might be involved in induction of clonal elimination of the self-reactive T cells. The proportion of V beta 6+ T cells present varied with the H-2 haplotype of the thymus and the cell types presenting Mls-1a products, which might be attributable to differences in the affinity of the H-2 products to T cell antigen receptors and differences in the amount of tolerogens expressed on the stromal cells.
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