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  • Title: A novel cytotoxic oxetane ent-kauranoid from Isodon japonicus.
    Author: Han Q, Zhang J, Lu Y, Wu Y, Zheng Q, Sun H.
    Journal: Planta Med; 2004 Jun; 70(6):581-4. PubMed ID: 15318402.
    Abstract:
    A novel ll,20: 1,20-diepoxy-ent-kaurane diterpenoid, maoyecrystal 1 (1), was isolated from Isodan japonicus, and its structure was elucidated by spectroscopic methods and comparison with another new ent-kauranoid, rubescensin W (2) from Isodon rubescens var. taihangensis. The structure of 2 was determined by single crystal X-ray diffraction analysis. A bioassay of their cytotoxity against K562 cells showed that the oxetane group of 1 might be a bioactive moiety.
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