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  • Title: The distribution of cis- and trans-acitretin in human epidermis.
    Author: Meyer E, Lambert W, De Leenheer A, De Bersaques J, Kint A.
    Journal: Br J Clin Pharmacol; 1992 Feb; 33(2):187-9. PubMed ID: 1532322.
    Abstract:
    The concentrations of trans-acitretin and its principal metabolite, cis-acitretin, were measured by h.p.l.c. after single and multiple dosing (50 mg orally for 13 days) in plasma, blister fluid and epidermal samples from four healthy male volunteers. Within-day epidermal concentrations of trans-acitretin exceeded those of the cis-form which were at the limit of assay sensitivity. No accumulation of trans-acitretin was observed in plasma or blister fluid but AUC values for the drug in blister roof cells tended to be higher after multiple dosing.
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