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  • Title: Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: metabolism-directed optimization studies towards orally bioavailable derivatives.
    Author: Vergne F, Bernardelli P, Lorthiois E, Pham N, Proust E, Oliveira C, Mafroud AK, Ducrot P, Wrigglesworth R, Berlioz-Seux F, Coleon F, Chevalier E, Moreau F, Idrissi M, Tertre A, Descours A, Berna P, Li M.
    Journal: Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4615-21. PubMed ID: 15324875.
    Abstract:
    The synthesis and optimization of pharmacokinetic parameters of structurally novel small PDE7 inhibitors is discussed.
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