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  • Title: Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1.
    Author: Lorthiois E, Bernardelli P, Vergne F, Oliveira C, Mafroud AK, Proust E, Heuze L, Moreau F, Idrissi M, Tertre A, Bertin B, Coupe M, Wrigglesworth R, Descours A, Soulard P, Berna P.
    Journal: Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4623-6. PubMed ID: 15324876.
    Abstract:
    The synthesis and SAR studies of spiroquinazolinones as novel PDE7 inhibitors are discussed. The best compounds from the series displayed nanomolar inhibitory affinity and were selective versus other PDE isoenzymes.
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