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  • Title: Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity.
    Author: Kamal A, Ramulu P, Srinivas O, Ramesh G, Kumar PP.
    Journal: Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4791-4. PubMed ID: 15324909.
    Abstract:
    Two types of benzimidazoles have been synthesized and linked to DC-81 at C8-position through different alkyl chain spacers. These PBD conjugates have exhibited remarkable DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.
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