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  • Title: Malignant transformation of endometriosis and genetic alterations of K-ras and microsatellite instability.
    Author: Amemiya S, Sekizawa A, Otsuka J, Tachikawa T, Saito H, Okai T.
    Journal: Int J Gynaecol Obstet; 2004 Sep; 86(3):371-6. PubMed ID: 15325855.
    Abstract:
    OBJECTIVES: To clarify the role of specific genetic alterations in the multi-step process of malignant transformation of endometriosis. METHODS: In cases of ovarian endometrioid carcinoma, we separated regions of normal endometriosis, atypical endometriosis and ovarian endometrioid carcinoma by laser microdissection, and examined K-ras mutation and microsatellite instability in each separated tissue sample. RESULTS: We detected K-ras mutation and microsatellite instability in endometrioid carcinoma tissue, but not in normal or atypical endometriosis bordering the cancerous region. CONCLUSIONS: The present findings suggest that K-ras mutation and microsatellite instability are associated with malignant transformation from atypical endometriosis to ovarian endometrioid carcinoma.
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