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  • Title: Lipid-altering changes and pleiotropic effects of atorvastatin in patients with hypercholesterolemia.
    Author: Sakabe K, Fukuda N, Wakayama K, Nada T, Shinohara H, Tamura Y.
    Journal: Am J Cardiol; 2004 Aug 15; 94(4):497-500. PubMed ID: 15325939.
    Abstract:
    In this prospective study, we found beneficial short-term effects from atorvastatin therapy, including effects on low-density lipoprotein subfractions and remnant-like lipoprotein particle cholesterol, antioxidant effects, and alterations in endothelial function that may be important in early benefit from statin therapy; some effects would support much earlier benefit than previously reported. We also found long-term effects of atorvastatin, including decreased plasminogen activator inhibitor type-1 and additional significant alterations in low-density lipoprotein subfractions and endothelial function, supporting benefits from continuous long-term atorvastatin therapy beyond early reversal of hypercholesterolemia.
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