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  • Title: Clinical impact of intravenous methylprednisolone in attacks of multiple sclerosis.
    Author: Nos C, Sastre-Garriga J, Borràs C, Río J, Tintoré M, Montalban X.
    Journal: Mult Scler; 2004 Aug; 10(4):413-6. PubMed ID: 15327039.
    Abstract:
    BACKGROUND: Intravenous methylprednisolone (IVMP) has been shown to hasten recovery from attacks of multiple sclerosis (MS) without altering the long term evolution of the condition; however, there is little evidence available to suggest which patients are more likely to benefit from IVMP treatment. OBJECTIVE: To measure clinical change after IVMP treatment and to identify predictors of good outcome. METHODS: Retrospective open-label study of medical records from 51 patients with clinically isolated syndromes or relapsing-remitting MS treated with IVMP for an acute attack (54 attacks). RESULTS: A measurable neurological improvement was observed at one month in 44% of these attacks; the only predictor of Expanded Disability Status Scale (EDSS) change at one month was the severity of the attack. CONCLUSION: Attack severity predicts good response to IVMP when measured by means of EDSS.
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