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  • Title: LcoP, an osmoregulated betaine/ectoine uptake system from Corynebacterium glutamicum.
    Author: Steger R, Weinand M, Krämer R, Morbach S.
    Journal: FEBS Lett; 2004 Aug 27; 573(1-3):155-60. PubMed ID: 15327991.
    Abstract:
    In Corynebacterium glutamicum, four uptake systems for compatible solutes have been characterized so far. DHPE (DeltabetPDeltaputPDeltaproPDeltaectP), a derivative of the C. glutamicum type strain ATCC 13032 carrying deletions in the corresponding genes, still showed a low betaine uptake rate of 1.4 nmol/(min mg cdm). Genome analyses revealed the presence of a putative carrier, named low capacity osmoregulated permease (LcoP), which shows similarities to compatible solute transporters of the betaine/carnitine/choline transporter (BCCT)-family. Deletion of lcoP in DHPE resulted in betaine and ectoine uptake deficiency. LcoP, a betaine and ectoine permease is regulated at the expression and the activity level by the external osmolality. Addition of local anesthetics modulated the activity of BCCT-family members BetP, EctP, and LcoP in a different manner, indicating a different type of lipid-protein interaction.
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