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  • Title: The growth factor IL-2 activates p21ras proteins in normal human T lymphocytes.
    Author: Graves JD, Downward J, Izquierdo-Pastor M, Rayter S, Warne PH, Cantrell DA.
    Journal: J Immunol; 1992 Apr 15; 148(8):2417-22. PubMed ID: 1532814.
    Abstract:
    The T cell growth factor IL-2 induces T cell progression through the cell cycle and ultimately controls T cell mitosis. Here we show that the guanine nucleotide-binding proteins p21ras may be involved in IL-2 signal transduction pathways. IL-2 causes a rapid and prolonged activation of p21ras in both murine and human T cells. The concentration-dependence of IL-2-mediated stimulation of p21ras correlated with IL-2 stimulation of T cell proliferation, which indicates that p21ras activity can be controlled by signals generated via the interaction between IL-2 and its high affinity cellular receptor. These results suggest that p21ras may play a role in the regulation of T cell growth by IL-2.
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