These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: IgG-associated mesangial glomerulonephritis in a patient with Down syndrome.
    Author: Assadi FK.
    Journal: Med Sci Monit; 2004 Sep; 10(9):CS54-6. PubMed ID: 15328491.
    Abstract:
    BACKGROUND: Patients with Down syndrome have a variety of urinary tract abnormalities including obstructive hydronephrosis, dysplasia, reflux nephropathy and glomerular lesions. However, primary glomerulonephritis with prominent IgG deposits has not been reported previously in this syndrome. CASE REPORT: A 17-year-old girl with Down syndrome presented with proteinuria and chronic renal insufficiency. A percutaneous renal biopsy revealed prominent IgG deposition without IgA or IgM deposits in the absence of an identifiable autoimmune disorder, or any other etiologic factors known to cause secondary IgG-associated glomerulonephritis. CONCLUSIONS: The glomerular lesion identified in the present case demonstrates a distinct entity that further expands the spectrum of renal disease known to occur in Down syndrome. Early detection of renal disorder in Down syndrome may prevent or slow down the progression.
    [Abstract] [Full Text] [Related] [New Search]