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  • Title: [Effects comparison of lamivudine therapy for hepatitis B virus genotypes B and C].
    Author: Zhou JL, Wu SP.
    Journal: Zhonghua Gan Zang Bing Za Zhi; 2004 Aug; 12(8):489-90. PubMed ID: 15329211.
    Abstract:
    OBJECTIVE: To determine the lamivudine response of HBV genotypes in patients with HBV DNA positive chronic hepatitis. METHODS: Clinical data from 235 patients in the original trial were analyzed. RESULTS: 135 patients received lamivudine and 100 patients as controls. Almost all patients had HBV genotypes B or C. Antiviral response were 92.9% and 75.9% in lamivudine-treated patients (chi-square = 6.628, P < 0.05) and 9.8% and 8.5% in untreated controls (P > 0.05) with HBV genotype B and C, respectively. The incidences of lamivudine-induced mutation in YMDD motif were 3.6% and 16.5% in HBV genotype B and C, respectively (chi-square = 5.508, P < 0.01). We identified HBV genotype B, elevated pretreatment alanine aminotransferase (ALT) levels, and low pretreatment HBV DNA levels as independent factors associated with antiviral response. CONCLUSION: HBV genotype B was associated with a higher rate of lamivudine-induced HBV DNA clearance and lower rate of lamivudine-induced YMDD mutation compared with genotype C. HBV genotypes may be an important determinant of lamivudine therapy of chronic hepatitis B.
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