These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The expression and prognostic value of alpha-, beta- and gamma-catenins in renal cell carcinoma.
    Author: Aaltomaa S, Lipponen P, Kärjä V, Lundstedt S, Lappi J, Kosma VM.
    Journal: Anticancer Res; 2004; 24(4):2407-13. PubMed ID: 15330191.
    Abstract:
    BACKGROUND: Catenins have prognostic value in several human tumours. The aim of the study was to analyse the prognostic value of catenin expression in a prospectively followed series of renal cell carcinoma. PATIENTS AND METHODS: One hundred and twenty-four renal cell carcinomas were prospectively followed-up for a mean of 3.5 years and the survival data of patients were related to standard prognostic factors and to the results of alpha-, beta- and gamma-catenin immunohistochemistry. The data of catenin immunohistochemistry were also related to the clinical and histopathological characteristics of the tumours. RESULTS: Low cytoplasmic alpha-catenin expression was related to lymphatic tumour growth (p=0.02) and to tumour necrosis (p=0.02). The weak expression intensity of beta-catenin on cell membranes was related to venous growth inside the tumour (p=0.02), extratumoural venous growth (p=0.03) and to perineural growth (p<0.001). Nuclear gamma-catenin expression was strongly associated with clear cell type (p=0.0001) and high WHO grade (p=0.038). Short recurrence-free survival was predicted by weak membranous alpha-catenin (p=0.015) and beta-catenin (p=0.006) expression intensity, while their cytoplasmic expression was of lower significance (p=0.07 and 0.045, respectively). All the conventional prognostic factors predicted short recurrence-free survival: Fuhrman classification (p=0.02), WHO grade (p=0.026), perineural growth (p=0.013), venous invasion (p=0.0024), tumour size (p=0.004) and T-category (p=0.0001). Independent predictors of short recurrence-free survival were weak membranous expression intensity of beta-catenin (RR=0.15, p=0.004), high T-category (RR=2.70, p=0.0001) and high WHO grade (RR=2.24, p=0.025). CONCLUSION: The results show that immunohistochemical analysis of beta-catenin expression may be used as an indicator of aggressiveness in renal cell carcinoma.
    [Abstract] [Full Text] [Related] [New Search]