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  • Title: Absence of BRAF gene mutations differentiates spitz nevi from malignant melanoma.
    Author: Mihic-Probst D, Perren A, Schmid S, Saremaslani P, Komminoth P, Heitz PU.
    Journal: Anticancer Res; 2004; 24(4):2415-8. PubMed ID: 15330192.
    Abstract:
    BACKGROUND: Distinction of Spitz nevus from malignant melanoma is sometimes difficult on the basis of conventional histology. A high rate of BRAF gene mutations in malignant melanomas (66%) and nevi (82%) has recently been reported. MATERIALS AND METHODS: We screened a series of 20 Spitz nevi for BRAF mutations in exons 11 and 15 by denaturing gradient gel electrophoresis (DGGE). RESULTS: BRAF mutations could not be identified in Spitz nevi. CONCLUSION: Our results show that mutations within the BRAF gene are useful markers for the differential diagnosis between Spitz nevus and malignant melanoma.
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