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Title: A practical method for the stereoselective generation of beta-2-deoxy glycosyl phosphates. Author: Oberthür M, Leimkuhler C, Kahne D. Journal: Org Lett; 2004 Aug 19; 6(17):2873-6. PubMed ID: 15330636. Abstract: Beta-2-Deoxy sugar nucleotides are substrates used by a variety of glycosyltransferases (Gtfs). We have developed a chemical route to synthesize beta-2-deoxy sugar phosphates that starts from alpha-glycosyl chlorides. Our approach reliably provides access to a range of NDP beta-2-deoxy sugars essential for studying glycosyltransferases involved in the synthesis of biologically active natural products.[Abstract] [Full Text] [Related] [New Search]