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  • Title: Nagelamides A-H, new dimeric bromopyrrole alkaloids from marine sponge Agelas species.
    Author: Endo T, Tsuda M, Okada T, Mitsuhashi S, Shima H, Kikuchi K, Mikami Y, Fromont J, Kobayashi J.
    Journal: J Nat Prod; 2004 Aug; 67(8):1262-7. PubMed ID: 15332839.
    Abstract:
    Eight new dimeric bromopyrrole alkaloids, nagelamides A-H (1-8) and a monomeric one, 9,10-dihydrokeramadine (9), have been isolated from the Okinawan marine sponge Agelas sp., and the structures were elucidated from spectroscopic data. Nagelamides A-H (1-8) exhibited antibacterial activity against Gram-positive bacteria. Nagelamide G (7) inhibited protein phosphatase 2A activity.
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