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  • Title: Lasonolides C-g, five new lasonolide compounds from the sponge Forcepia sp.
    Author: Wright AE, Chen Y, Winder PL, Pitts TP, Pomponi SA, Longley RE.
    Journal: J Nat Prod; 2004 Aug; 67(8):1351-5. PubMed ID: 15332854.
    Abstract:
    Five new marine-derived macrolide compounds, lasonolides C (3), D (4), E (5), F (6), and G (7), have been isolated from the sponge Forcepia sp. along with the parent compound in the series, lasonolide A (1). Their structures were elucidated on the basis of spectral data. Compounds 3-5 inhibit the in vitro proliferation of A-549 human lung adenocarcinoma cells with IC50's of 0.13, 4.5, and 0.31 microM, respectively. Compounds 3-6 inhibit the in vitro proliferation of PANC-1 human pancreatic carcinoma cells with IC50's of 0.38, 4.89, 0.57, and 15.6 microM, respectively. Compound 3 inhibits the in vitro proliferation of the NCI-ADR-RES cell line with an IC50 of 1.12 microM.
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