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  • Title: [Comparative characteristics of immunological, clinical and morphological features of human lymphoid tumors in respect with tumor genesis and progression].
    Author: Gretsov EM, Churakova ZhV, Sheval' EV, Vorob'ev IA.
    Journal: Ontogenez; 2004; 35(3):229-38. PubMed ID: 15334826.
    Abstract:
    We describe three lymphoid tumors with the same immunophenotype characteristic for chronic lymphoid leukemia (CD19+/CD5+, clonality of the light immunoglobulin chains, CD23+ and CD10-). However, clinical picture and morphology of neoplastic cells dictate different clinical forms of these cases: chronic lymphoid leukemia, large cell transformation of chronic lymphoid leukemia and diffuse large B-cell lymphoma. Taking into account that immunophenotype reflects the origin of tumor, while clinical outcome and morphological features of cells reflect the stage of tumor progression and/or pathway of tumor formation, we discuss the approach to natural classification of lymphoid tumors based on the process of their evolution.
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