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  • Title: Multiple myeloma complicated by autoimmune hemolytic anemia.
    Author: Wada H, Yata K, Mikami M, Suemori S, Nakanishi H, Kondo T, Tsujioka T, Suetsugu Y, Otsuki T, Sadahira Y, Yawata Y, Sugihara T.
    Journal: Intern Med; 2004 Jul; 43(7):595-8. PubMed ID: 15335188.
    Abstract:
    A 57-year-old man was admitted with severe anemia and hypergamma globulinemia. After a diagnosis of multiple myeloma and autoimmune hemolytic anemia was made, chemotherapy rapidly decreased the M-protein level and improved his anemia with normalization of the direct Coombs test. The immunoglobulin binding to the patient's red cells was immunoglobulin G kappa chain like the myeloma M-protein. However, monoclonal immunoglobulin G derived from short-term culture of the patient's bone marrow mononuclear cells did not bind to a panel of red cells. Therefore, the relationship between the M protein produced by his myeloma cells and hemolysis remained unclear.
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