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  • Title: Nicorandil associated anal ulceration.
    Author: Watson A, Suttie S, Fraser A, O'Kelly T, Loudon M.
    Journal: Colorectal Dis; 2004 Sep; 6(5):330-1. PubMed ID: 15335365.
    Abstract:
    OBJECTIVE: Nicorandil is a vasodilator used to control angina. It has been associated with oral and anal ulceration that resolves upon withdrawal of the drug. PATIENTS AND METHODS: We report a series of 13 patients with nonspecific anal ulceration all of whom were receiving nicorandil for control of symptoms of ischaemic heart disease. RESULTS: All the ulcers had similar clinical and histological appearances. All the ulcers healed on withdrawal of the drug. CONCLUSION: Nicorandil-associated anal ulceration should be considered in the differential diagnoses of nonhealing anal ulcers.
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