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  • Title: Identification of a promoter motif regulating the major DNA damage response mechanism of Mycobacterium tuberculosis.
    Author: Gamulin V, Cetkovic H, Ahel I.
    Journal: FEMS Microbiol Lett; 2004 Sep 01; 238(1):57-63. PubMed ID: 15336403.
    Abstract:
    The principal response of many bacteria to DNA damage is mediated by a mechanism dependent on the LexA and RecA proteins. However, Mycobacterium tuberculosis was recently reported to regulate a majority of DNA repair genes independently of RecA and LexA, suggesting that an unknown RecA/LexA-independent mechanism controls the major DNA damage response pathway in this organism. Here we have identified a motif tTGTCRgtg-8nt-TAnnnT that defines a novel RecA/LexA-independent promoter (RecA-NDp) of M. tuberculosis. Furthermore, we show that the RecA-NDp type of promoter precedes DNA repair genes in other Actinomycetales.
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