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  • Title: Distribution and MK-801-induced expression of serine racemase mRNA in rat brain by real-time quantitative PCR.
    Author: Yoshikawa M, Kobayashi T, Oka T, Kawaguchi M, Hashimoto A.
    Journal: Brain Res Mol Brain Res; 2004 Sep 10; 128(1):90-4. PubMed ID: 15337321.
    Abstract:
    We have used real-time quantitative PCR methods to evaluate the effect of the systemic administration of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801; 0.4 mg/kg) on the gene expression of serine racemase in several brain areas of the rat. The levels of serine racemase mRNA in all the brain areas transiently increased after the administration. The present findings suggest that there is a link between the expression of serine racemase mRNA and the activity of the NMDA receptors.
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