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  • Title: Interleukin-1 gene cluster polymorphisms and risk of Alzheimer's disease in Chinese Han population.
    Author: Li XQ, Zhang JW, Zhang ZX, Chen D, Qu QM.
    Journal: J Neural Transm (Vienna); 2004 Sep; 111(9):1183-90. PubMed ID: 15338333.
    Abstract:
    Interleukin-1 (IL-1) has been implicated as a key cytokine in Alzheimer's disease (AD) pathogenesis. IL-1 gene polymorphisms, especially IL-1A C((-)889)T polymorphism, have been suggested to be associated with AD risk and onset age. To determine if IL-1 polymorphisms are genetic risk factors for developing AD in Chinese Mainland population, we analyzed IL-1A ((-)889), IL-1B ((-)511) and IL-1RN variable number of tandem repeat (VNTR) polymorphisms in a sample of 145 sporadic AD patients and 181 healthy controls. Our data revealed that the three polymorphisms in IL-1 gene cluster might not play a key role in AD pathogenesis in Chinese Mainland Han population.
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