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  • Title: Granular cell tumor of the breast preoperatively diagnosed by fine-needle aspiration cytology: report of a case.
    Author: Akatsu T, Kobayashi H, Uematsu S, Tamagawa E, Shinozaki H, Kase K, Kobayashi K, Otsuka S, Mukai M, Kitajima M.
    Journal: Surg Today; 2004; 34(9):760-3. PubMed ID: 15338349.
    Abstract:
    Granular cell tumors (GCTs) have a characteristic cytological appearance, and fine-needle aspiration cytology (FNAC) has been suggested to be the diagnostic modality of choice. However, the differential diagnosis has not yet been well described. We herein describe a rare case of GCT of the breast and discuss the differential diagnosis. A 53-year-old woman presented to our hospital with a left breast mass. In clinical and radiological examinations, the mass was suspected to be malignant. Cytologically, the tumor was composed of cohesive groups of cells with a syncytial appearance, and the cells contained abundant, finely eosinophilic cytoplasmic granules and small round-to-slightly-oval nuclei, thus suggesting the presence of benign GCT. The results of immunohistochemical staining supported the proposed deviation from Schwann cells. This case emphasizes the fact that GCTs are a rare but important possibility in the differential diagnosis of breast tumors, and that FNAC may provide clinically useful information on the management of such lesions.
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