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Title: First catalytic asymmetric synthesis of beta-amino-beta-polyfluoroalkyl ketones via proline-catalysed direct asymmetric carbon-carbon bond formation reaction of polyfluoroalkylated aldimines. Author: Funabiki K, Nagamori M, Goushi S, Matsui M. Journal: Chem Commun (Camb); 2004 Sep 07; (17):1928-9. PubMed ID: 15340605. Abstract: Proline-catalysed direct asymmetric carbon-carbon bond formation reaction of polyfluoroalkylated aldimines with acetone afforded the corresponding beta-(p-methoxyphenyl)amino-beta-polyfluoroalkyl ketones in high enantioselectivities (up to 98% ee).[Abstract] [Full Text] [Related] [New Search]