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  • Title: Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP.
    Author: Yu CY, Asano N, Ikeda K, Wang MX, Butters TD, Wormald MR, Dwek RA, Winters AL, Nash RJ, Fleet GW.
    Journal: Chem Commun (Camb); 2004 Sep 07; (17):1936-7. PubMed ID: 15340609.
    Abstract:
    L-DMDP, prepared from D-gulonolactone, is a highly specific inhibitor of a number of plant and mammalian alpha-glucosidases [between 2 and 4 orders of magnitude more potent than the enantiomeric natural product DMDP] but is not an inhibitor of bacterial and yeast alpha-glucosidases. Additionally N-butyl-DMDP is a potent inhibitor of ceramide-specific glucosyltransferase but N-butyl-L-DMDP shows no inhibition.
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