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  • Title: Effectiveness of oral propafenone for the prevention of atrial fibrillation after coronary artery bypass grafting.
    Author: Kowey PR, Yannicelli D, Amsterdam E, COPPA-II Investigators.
    Journal: Am J Cardiol; 2004 Sep 01; 94(5):663-5. PubMed ID: 15342305.
    Abstract:
    The efficacy and safety of oral propafenone for the prevention of atrial fibrillation (AF) were tested in a group of 293 patients who underwent coronary artery bypass grafting. Patients were randomized to placebo or 1 of 2 doses of propafenone. Patients treated with propafenone 675 mg/day compared with placebo had a nonsignificantly reduced incidence of AF and did not have a reduction in length of stay. Adverse events and discontinuations for untoward events were equal among the 3 groups.
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