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  • Title: Usefulness of rh-G-CSF in early-onset severe neutropenia in neonatal lupus syndrome.
    Author: Zuppa AA, De Luca D, De Turris P, Cota F, Tortorolo G.
    Journal: J Pediatr Hematol Oncol; 2004 Sep; 26(9):609-11. PubMed ID: 15342991.
    Abstract:
    Neutropenia is a mild and transient manifestation of neonatal lupus syndrome (NLS) in the second or third month of life. The authors describe a newborn with an early-onset severe neutropenia due to anti-Ro/SSA. In the second day of life, neutropenia has been treated with recombinant human granulocyte colony-stimulating factor (rh-G-CSF). This is the first case in which rh-G-CSF was used in NLS, and the authors studied the pharmacologic action of the drug in relationship to the pathophysiology of NLS.
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