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  • Title: HLA-G protein concentrations in maternal serum and placental tissue are decreased in preeclampsia.
    Author: Yie SM, Li LH, Li YM, Librach C.
    Journal: Am J Obstet Gynecol; 2004 Aug; 191(2):525-9. PubMed ID: 15343231.
    Abstract:
    OBJECTIVE: The aim of this study were to determine whether soluble human leukocyte antigen-G protein levels in serum and/or human leukocyte antigen protein in placental tissues differ between women with preeclampsia versus uncomplicated pregnancies. Study design human leukocyte antigen-G levels were determined with the use of a specific enzyme-linked immunosorbent assay in 20 subjects with preeclampsia and 14 normal control subjects. RESULTS: Both serum and placental human leukocyte antigen-G levels were decreased significantly in the preeclampsia group (median, 0.026 microg/mL in serum; median, 0.026 microg/mg protein in placenta), in comparison with normal pregnant women (median, 0.093 microg/mL in serum; median, 0.088 microg/mg protein in placenta; P=.0112 and P=.0406, respectively). There was a significant correlation between serum and placental human leukocyte antigen-G levels (r=0.603; P=0.0002). CONCLUSION: The reduced expression of placental human leukocyte antigen-G and reduced release of this protein into the maternal circulation in preeclampsia may alter the maternal-fetal immune relationship and thus be involved in the cause of this disorder.
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