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  • Title: [Plasma lipoprotein (a) values in familial defective ligand apo B 100 in a South European population].
    Author: Ejarque I, Leal JT, Ascaso JF, Chaves FJ, Milian E, Priego MA, Carmena R.
    Journal: An Med Interna; 2004 Jul; 21(7):322-5. PubMed ID: 15347236.
    Abstract:
    AIMS: 1) to study lipoprotein (a) (Lp(a)) plasma values in subjects with familial ligand-defective apo B 100 (FDB). METHODS: We studied 19 heterozygous FDB subjects (8 males) from 12 families, carriers of R3500Q mutation on apo B gene and 90 controls (34 males). The genetic diagnosis was established with PCR-SSCP analysis and automatic sequencing. In all subjects plasma lipids, apolipoprotein B and Lp(a) levels were determined with standard procedures. RESULTS: Subjects carriers of R3500Q mutation on apo B gene have significantly higher plasma Lp(a) and log transformed Lp(a) values and prevalence of Lp(a) > 30 cut point for coronary heart disease than controls. CONCLUSIONS: Subjects with FDB showed higher Lp(a) plasma values than controls, although the mechanism and the clinical consequences of these result are not known.
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