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  • Title: Histamine N-methyltransferase controls the contractile response of guinea pig trachea to histamine.
    Author: Ohrui T, Yamauchi K, Sekizawa K, Ohkawara Y, Maeyama K, Sasaki M, Takemura M, Wada H, Watanabe T, Sasaki H.
    Journal: J Pharmacol Exp Ther; 1992 Jun; 261(3):1268-72. PubMed ID: 1534842.
    Abstract:
    The contractile response of isolated guinea pig trachea to histamine was potentiated in the presence of the histamine N-methyltransferase (HMT) inhibitor SKF 91488, whereas the diamine oxidase inhibitor aminoguanidine was without effect. SKF 91488 shifted in a concentration-dependent fashion the concentration-response curves to histamine to lower concentrations with the maximum by 1 log unit. The trachea contained significant HMT activity (45.4 +/- 5.0 pmol/min/mg protein). In situ hybridization to detect HMT mRNA indicated that HMT mRNA was present in the epithelium and endothelium, being more abundant in the former. Removal of the epithelium shifted the concentration-response curves to histamine to lower concentrations by 0.8 log unit, and SKF 91488 caused only a slight shift of histamine concentration-response curves in tissues denuded of epithelium. These findings suggest that HMT regulates the contractile response of guinea pig trachea to histamine, and epithelial removal-induced bronchial hyperresponsiveness to histamine is largely explained by the loss of HMT in the epithelium.
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