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  • Title: [The biological effect of retinoic acid on cultured human periodontal ligament cells].
    Author: Wang Y, Wang SZ, Yang PS, Li S.
    Journal: Shanghai Kou Qiang Yi Xue; 2004 Aug; 13(4):297-300. PubMed ID: 15349671.
    Abstract:
    PURPOSE: To evaluate the biological effect of retinoic acid on cultured human periodontal ligament cells. METHODS: Human periodontal ligament cells were cultured and challenged by retinoic acid with different concentrations. The cell morphology was observed under phase-contrast microscope; the cell proliferation activity was examined using MTT; the alkaline phosphatase activity was measured by enzyme kinetics method; the total amount of protein was assayed at different times. RESULTS: Retinoic acid enhanced alkaline phosphatase activity and had no effect on morphology, proliferation and total protein synthesis of periodontal ligament cells. CONCLUSION: Retinoic acid improves periodontal ligament cells to differentiate into osteoblast like cells.
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