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  • Title: Checkpoints in ER-associated degradation: excuse me, which way to the proteasome?
    Author: Ahner A, Brodsky JL.
    Journal: Trends Cell Biol; 2004 Sep; 14(9):474-8. PubMed ID: 15350974.
    Abstract:
    The failure of secreted proteins to fold results in their retrotranslocation from the endoplasmic reticulum (ER) and degradation by the proteasome in a process called "ER-associated degradation" (ERAD). Two recent studies indicate that ERAD substrates are targeted to different pathways depending on the topology of the substrate and the subcellular location of the misfolded domain.
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