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  • Title: Chiral separation of omeprazole and several related benzimidazoles using supercritical fluid chromatography.
    Author: del Nozal MJ, Toribio L, Bernal JL, Alonso C, Jiménez JJ.
    Journal: J Sep Sci; 2004 Aug; 27(12):1023-9. PubMed ID: 15352722.
    Abstract:
    A study of the enantiomeric separation of omeprazole and several related benzimidazoles, using supercritical fluid chromatography (SFC), on the amylose based column Chiralpak AD is presented in this work. The effect of the organic modifier as well as temperature on the retention and enantioresolution was investigated. Alcohol-type modifiers provided the best results, allowing the enantiomeric separation of all the compounds studied with resolutions that were in most cases higher than 2, and analysis times lower than 10 minutes. An investigation of the temperature effect revealed that the isoelution temperature was below the working temperature range in only two cases, and hence it was better to work at the highest temperature permitted.
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