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  • Title: Enoximone in newborns with refractory postoperative low-output states (LOS).
    Author: Hausdorf G, Friedel N, Berdjis F, Dieterich HA, Fell JJ, Dressler HT, Werneyer A, Hetzer R, Lange PE.
    Journal: Eur J Cardiothorac Surg; 1992; 6(6):311-7. PubMed ID: 1535503.
    Abstract:
    Enoximone was administered to 16 newborns with postoperative, catecholamine-refractory cardiac low-output states in addition to high-dose catecholamine treatment. Haemodynamic changes were assessed at baseline and during treatment. Haemodynamic parameters were improved in 12 newborns ("responders"), 9 of these survived. Three responders died; one from cardiac low-output and 2 from uncorrectable congenital heart disease verified by autopsy. Four newborns did not respond to enoximone therapy ("non-responders") and died. The haemodynamic effects of enoximone were characterized by an increase in cardiac index (+160%, P less than 0.0008), and a fall in right (-26%, P less than 0.0004) and left (-34%, P less than 0.003) atrial pressures. It is concluded that enoximone can be an effective agent in the treatment of cardiac low-output states refractory to high-dose catecholamines in neonates up to 7 months old.
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