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  • Title: Selective inhibition of cough and bronchoconstriction in conscious guinea pigs.
    Author: Forsberg K, Karlsson JA, Zackrisson C, Persson CG.
    Journal: Respiration; 1992; 59(2):72-6. PubMed ID: 1535722.
    Abstract:
    In guinea-pigs citric acid-induced cough and bronchoconstriction were inhibited by beta 2-agonist and xanthine drugs. Lidocaine inhibited only cough. Cromoglycate and ipratropium bromide inhibited only bronchoconstriction. We conclude that cough and bronchoconstriction in guinea-pigs are distinct reflexes and that the inhibitory pharmacology of these airway reflexes may agree in many respects, with that observed in asthmatic subjects.
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