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  • Title: Synthesis of an unusual branched-chain sugar, 5-C-methyl-L-idopyranose for SAR studies of pyranmycins: implication for the future design of aminoglycoside antibiotics.
    Author: Wang J, Li J, Czyryca PG, Chang H, Kao J, Chang CW.
    Journal: Bioorg Med Chem Lett; 2004 Sep 06; 14(17):4389-93. PubMed ID: 15357959.
    Abstract:
    The syntheses of a challenging branched-chain sugar and several L-sugars have been accomplished. Their application in studies of the antibacterial activity of pyranmycins is reported, which could provide new strategies for the future design of aminoglycoside antibiotics.
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