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  • Title: Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity.
    Author: Shin DY, Kim SN, Chae JH, Hyun SS, Seo SY, Lee YS, Lee KO, Kim SH, Lee YS, Jeong JM, Choi NS, Suh YG.
    Journal: Bioorg Med Chem Lett; 2004 Sep 06; 14(17):4519-23. PubMed ID: 15357984.
    Abstract:
    Syntheses and excellent anti-MRSA activities of the mansonone F analogs are reported. In addition, the minimal structural requirements for its anti-MRSA activities as well as its structure-activity relationship including the C3 substituents effects on anti-MRSA activity are also described. In particular, this study revealed that both ortho-quinone and tricyclic systems of mansonone F are essential for anti-MRSA activities.
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