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  • Title: Public, private and non-specific antibodies induced by non-cytopathic viral infections.
    Author: Recher M, Hunziker L, Ciurea A, Harris N, Lang KS.
    Journal: Curr Opin Microbiol; 2004 Aug; 7(4):426-33. PubMed ID: 15358263.
    Abstract:
    Lymphocytic choriomeningitis virus (LCMV) represents a useful experimental model of murine infection with a non-cytopathic virus, bearing resemblance to HIV and hepatitis C virus (HCV) infections in humans. Recent data from the LCMV model indicate that the humoral immune response that is induced by non-cytopathic viruses is far more complex than previously appreciated. LCMV-induced IgG production is largely polyclonal, with more than 90% of the antibody repertoire constituting non-relevant specificities. A delayed virus-neutralizing antibody response is induced, including specificities directed not only against the parental LCMV-strain present in the host but also cross-specifically against LCMV-variants isolated from other hosts. These findings provide novel insights to aid our understanding of clinically relevant observations that are recorded following human infection with HIV, HCV and dengue viruses.
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