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  • Title: [Expression of P53, P63, and C-erbB-2 in endometrioid adenocarcinoma and their clinicopathological significance].
    Author: Hu WF, Liu MQ, Zhao Q.
    Journal: Ai Zheng; 2004 Sep; 23(9):1021-5. PubMed ID: 15363194.
    Abstract:
    BACKGROUND & OBJECTIVE: Tumor suppressor gene p53 and oncogene C-erbB-2 are confirmed to have close relation with endometrioid adenocarcinoma (EC), few documents have been reported about their correlation. Its structural homology to p53, p63 has been considered as a tumor suppressor gene acompany with p53 mutation, but its suppressive nature has not been confirmed yet; reports about p63 expression in EC are rare. This study was designed to investigate the roles of p53, p63, and C-erbB2 in tumorigenesis and development of EC, and their correlation with clinicopathological features of EC. METHODS: Immunohistochemical technique was used to detect P53, P63, and C-erbB2 protein expression in 38 cases of EC, 23 cases of endometrial hyperplasia (EH), and 10 cases of benign proliferative endometrium (BPE). RESULTS: (1) The positive rate of P53 in EC was 31.6%,significantly higher than those in EH and BPE (P < 0.05). P53 expression was associated with surgical pathologic stage, and depth of myometrial invasion in EC (P< 0.005), but was not associated with histological grade (P >0.05). (2) The positive rate of P63 in EC was 81.6%, significantly higher than those in EH and BPE (P < 0.005). P63 expression was not associated with histological grade, surgical pathologic stage, and depth of myometrial invasion in EC (P >0.05). (3) The positive rate of C-erbB-2 in EC was 23.2%, there was no significant difference compared with those in EH or BPE (P >0.05).C-erbB-2 expression was associated with surgical pathologic stage, and depth of myometrial invasion in EC (P< 0.001,P< 0.005),but was not associated with histological grade (P >0.05).(4) There was significantly positive correlation between P53 and P63 (r =0.443,P < 0.01)or C-erbB-2 (r =0.490,P < 0.005). CONCLUSIONS: Both p53 and p63 are involved in carcinogenesis of EC; p63 may act as an oncogene in tumorigenesis of EC. The expression of P53 and C-erbB2 are related to the progression of malignant EC; P53 and C-erbB-2 co-expression may predict poor prognosis.
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