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  • Title: Integrin-linked kinase: integrin's mysterious partner.
    Author: Grashoff C, Thievessen I, Lorenz K, Ussar S, Fässler R.
    Journal: Curr Opin Cell Biol; 2004 Oct; 16(5):565-71. PubMed ID: 15363808.
    Abstract:
    Integrin-mediated cell adhesion regulates a vast number of biological processes including migration, survival and proliferation of cells. It is therefore not surprising that defects in integrin function are often rate-limiting for development and profoundly affect the progression of several diseases. The functions of integrins are mediated through the recruitment of cytoplasmic plaque proteins. One of these is integrin-linked kinase, which connects integrins to the actin cytoskeleton and transduces signals through integrins to the extracellular matrix and from integrins to various subcellular compartments.
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