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  • Title: Eph/ephrin signaling in morphogenesis, neural development and plasticity.
    Author: Klein R.
    Journal: Curr Opin Cell Biol; 2004 Oct; 16(5):580-9. PubMed ID: 15363810.
    Abstract:
    Ephrins are cell-surface-tethered ligands for Eph receptors, the largest family of receptor tyrosine kinases. During development, the Eph/ephrin cell communication system appears to influence cell behavior such as attraction/repulsion, adhesion/de-adhesion and migration, thereby influencing cell fate, morphogenesis and organogenesis. During adulthood, the Eph/ephrin system continues to play roles in tissue plasticity, for example in shaping dendritic spines during neuronal plasticity. Mechanistically, Eph-ephrin repulsive behavior appears to require ligand-receptor internalization and signaling to Rho GTPases.
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