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  • Title: N- t-Boc-amino acid esters of isomannide. Potential inhibitors of serine proteases.
    Author: Muri EM, Gomes M, Costa JS, Alencar FL, Sales A, Bastos ML, Hernandez-Valdes R, Albuquerque MG, da Cunha EF, Alencastro RB, Williamson JS, Antunes OA.
    Journal: Amino Acids; 2004 Oct; 27(2):153-9. PubMed ID: 15365909.
    Abstract:
    Hepatitis C, Dengue and West Nile virus are some of the most important flaviviruses, that share one important serine protease enzyme. Serine proteases are the most studied class of proteolytic enzyme and, in these cases, a primary target for drug discovery. In this paper, we describe the synthesis and preliminary molecular modeling studies of a novel class of N- t-Boc amino acid esters derived of isomannide as potential serine proteases inhibitors.
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